[The optimization of the hypotensive therapy of hypertension patients taking into account the central hemodynamics and functional tests with obzidan and prazosin]. / Optimizatsiia gipotenzivnoi terapii bol'nykh gipertonicheskoi bolezn'iu s uchetom tsentral'noi gemodinamiki i funktsional'noi proby s ispol'zovaniem obzidana i prazozina.

A study of 52 patients with hypertensive disease (grade II, age--from 30 to 50 years; men--32, women--24) using functional tests with physical loads revealed that pronounced hemodynamic changes were seen in patients with the hyperkinetic type of hemodynamics. Obsidan and prazosin reduced the degree of responses to physical loads, economy of energy expenses, increased tolerance to physical work. Association of pharmacological tests with functional physical loads in patients with hypertensive disease allows to realize selection of hypotensive drugs depending on the hemodynamic variant of the course of the pathological process and evaluate the adequacy of dosages for treatment courses.

[Circulatory insufficiency in the light of neuroendocrine and metabolic disorders]. / Nedostatochnost' krovoobrashcheniia v svete neiro-endokrinnykh i obmennykh narushenii.

Certain metabolic disorders characterizing disturbances both in neuroendocrine control and in metabolic processes at the cell and tissue levels were revealed in 472 patients with rheumatic heart disease, atherosclerotic cardiosclerosis, and cor pulmonale. The disturbance in the adrenal function was of a dissociated character, manifested by increase in sympathoadrenal and decrease in glucocorticoid activity. The indices of pentosophosphate cycle and erythrocyte and blood serum enzymes studied testify to deep changes in the state of the erythron, marked both by breaks and by adaptation to hypoxia caused by circulatory insufficiency.